Answer Common Questions

When pharmacists and their teams can answer common questions about the COVID-19 vaccines clearly, it builds vaccine confidence in the patients they serve. With new information coming out daily, it can be hard to have the right things to say when patients ask questions.

APhA is working with pharmacists to gather and answer some of the most frequently asked questions from patients. Find answers when you click on each question below, as well as more information and related printable resources you can provide to patients during the interaction.


Podcast: COVID-19 Vaccine Safety and Effectiveness

Dr. Michael Hogue, dean of the Loma Linda University College of Pharmacy, talks frankly about the safety and effectiveness of the COVID-19 vaccines.

Listen on SoundCloud

Safety and Efficacy

Are COVID-19 vaccines safe?
  • Yes. Hundreds of millions of people around the world have received COVID-19 vaccines and the results of ongoing safety monitoring are reassuring.
  • Vaccines work by teaching the body to recognize and fight off the virus that causes COVID-19. After vaccination, people may notice their body gearing up to make antibodies and build immunity. Sometimes this means people feel feverish, nauseous, achy, or tired, and they may have a headache or a sore arm in the first few days after vaccination. These symptoms typically resolve on their own within a day or two.
  • Any vaccination can result in a severe allergic reaction (called anaphylaxis), but these events are very rare (roughly 1 case per 200,000 to 1 million vaccinations), and every vaccination site has epinephrine (Adrenalin®) on hand to treat such rare reactions.
  • A rare bleeding condition was identified within a couple weeks after several people received the Johnson & Johnson/Janssen COVID-19 vaccine. That condition is called thrombosis-with-thrombocytopenia syndrome (TTS), which is bleeding with low platelet counts. Discuss this situation with your vaccine provider.

Learn More

Information for Patients

CDC’s Safety of COVID-19 Vaccines

Can I get COVID-19 from a vaccine?
  • No. None of the vaccines contain the live COVID-19 virus that causes COVID-19.
  • It takes a few weeks for the body’s immune system to build a defense that protects against COVID-19, so it is possible some people might become infected with COVID-19 during this period.
  • No vaccine is perfectly protective. It is possible for a small percentage of vaccinated people to be infected with COVID-19 despite vaccination. These people typically develop only a mild case of COVID-19.
  • Patients may experience common postvaccination symptoms that feel like a COVID-19 infection, such as fever, fatigue, chills, and nausea.
Why would I want the COVID-19 vaccine if I already had COVID-19?
  • It is true that people with a previous COVID-19 infection will have some protection against the virus for a period of time afterward.
  • It is unclear whether people who were previously infected with the original COVID-19 virus will be protected against the emerging COVID-19 variants.
  • Studies show that the COVID-19 vaccines are effective in preventing COVID-19 infection and that they help protect against COVID-19 variants.
  • If patients express anxiety about the vaccine’s effect on them given their previous infection, encourage them to consider how they would feel if they were reinfected. Help them understand that getting vaccinated will prevent another infection, even if the vaccine causes the usual mild side effects they may feel for a couple days.

Learn More

Quick Tip

How can pharmacists convey the importance of getting vaccinated to individuals who already had COVID-19?

Why should I trust that the COVID-19 vaccines are safe when the news keeps talking about side effects?
  • It is true that more experience keeps showing us new information, and we learn new things as time goes by because our safety monitoring systems are working.
  • People can expect some side effects from the vaccine like headache, muscle ache, tiredness, or a slight fever. Such side effects reflect that the body is building an immune response that will protect against COVID-19. It is also important to remind patients that even if they don’t experience these symptoms, the vaccine is still working.
  • There are reports of rare but more serious adverse events after vaccination. Most COVID-19 vaccine recipients do not develop these symptoms.
  • Patients may not be aware that they can track their symptoms using v-safe, which is an app that will let them know symptoms they experience are reason to follow up with a doctor.

Patient Information

CDC’s summary of Selected Adverse Events Reported after COVID-19 Vaccination helps patients understand what we know about emerging, rare, adverse events after vaccination.

What if there are unknown delayed side effects?
  • Delayed side effects from vaccines are extremely rare. Considering the dozens of vaccines developed over the last 100 years, vaccine-related side effects are almost always detected within 6 weeks after vaccination.
  • None of the COVID-19 vaccines were authorized until clinical trial volunteers were monitored for at least 2 months. Those volunteers have now been followed for 6 months or more. In addition, an extensive network of safety monitoring is in place to rapidly detect any potential safety issues.
  • Once the vaccine teaches your body to recognize and fight off the COVID-19 virus, the vaccine is cleared from your body, which is what makes long-term side effects from vaccines so rare.

Learn More

Watch APhA’s Open Forum Webinar on The Long-term Effects of COVID-19 Disease: Impact on Patient Care to learn about the long-term effects of COVID-19 disease and the advantages of COVID-19 vaccination.

Are the COVID-19 vaccines effective?
  • Yes, very effective. Several clinical trials of 40,000 volunteers each showed that these vaccines are highly effective at preventing COVID-19 infection, especially severe COVID-19 disease. Additional evidence gathered as hundreds of millions of people worldwide have been vaccinated (“real-world studies”) confirmed the findings of the clinical trials: the vaccines are very effective at reducing the risk of COVID-19 disease.
  • One study in the United States looked at nearly 4,000 vaccinated people given either Pfizer-BioNTech or Moderna COVID-19 vaccines. These included health care personnel, first responders, and other essential workers who were tested weekly for COVID-19 to determine how well the vaccines work. Those who were fully vaccinated were 90% less likely to get COVID-19 disease.
  • Another study in the United States found that fully vaccinated adults over the age of 65 years were 94% less likely to be hospitalized from COVID-19.

Quick Tip

How can pharmacists address concerns about breakthrough cases to build and maintain vaccine confidence?

Learn More

Know the research on the effectiveness of the COVID-19 vaccines.

Information for Patients

CDC’s COVID-19 Vaccines Work

Quick Tip

How can pharmacists discuss the potential need for booster doses?

Additional Resources